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MİKOZİS FUNGOİDES


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Medicine and Hematology Glossary

MİKOZİS FUNGOİDES

(Medicine and Hematology Glossary) :
Epidermotrofik T lenfositlerden köken alan cilt lenfoması. Etyolojisi bilinmiyor. Tümör hücreleri serebriform çekirdekli küçük lenfositlerdir. Epidermisi infiltre ederler. Lenf bezi infiltrasyonu varsa parakortikal bölgededir. Kemik iliği genellikle normaldir. Görülme yaşı ortalama 50'dir. Erkeklerde daha sıktır. Olguların çoğunda yardımcı T lenfosit (CD4) fenotipi vardır. Tanı genellikle zordur. Hastalarda uzun yıllar süren non-spesifik dermatit öyküsü vardır. Nörodermatitler, parapsöriasis, tinea corporis ve primer cild kanserleri gibi gibi cild hastalıklarından ayırımı gerekir. MF cilt lezyonları erken devre (eritem), plak devresi ve tümör devresi olarak 3 evrede izlenir. Hemen tüm organ ve dokularda yerleşim gösterebilir. En sık lenf bezlerinde saptanır. Lenf bezi tutulumu geç ortaya çıkan bir bulgudur. Hastalar tüm organ tulumu yönünden dikkatle değerlendirilmelidir.
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